Regulation of Membrane Cholecystokinin-2 Receptor by Agonists Enables Classification of Partial Agonists as Biased Agonists
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چکیده
منابع مشابه
New MT2 Melatonin Receptor-Selective Ligands: Agonists and Partial Agonists
The search for melatonin receptor agonists and antagonists specific towards one of the receptor subtypes will extend our understanding of the role of this system in relaying circadian information to the body. A series of compounds derived from a hit compound discovered in a screening process led to powerful agonists specific for one of the isoform of the melatonin receptor namely, MT₂. The comp...
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New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...
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The neurotransmitter dopamine has been implicated in the aetiology of brain disorders such as Parkinson’s disease and schizophrenia, and dopamine receptors provide important targets for anti-parkinsonian and antipsychotic drugs. In particular, the beneficial use of dopamine D2 or DI/D2 agonists in the drug treatment of Parkinson’s disease is now well established [l], although the ideal agonist ...
متن کاملNicotine receptor partial agonists for smoking cessation.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.196048